User:ProteinBoxBot/PBB Log Wiki 11-8-2007 A-6

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Log file for Protein Box Bot

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Log page index: User:ProteinBoxBot/PBB_Log_Index

Protein Status Quick Log - Date: 20:51, 8 November 2007 (UTC)

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Proteins without matches (22)

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ICAM3 NOTCH4 ITGB5 MDM4 JUNB
GNAO1 HLA-DMB PSMA6 DOK1 RBPJ
CYB5R3 PRKAA1 DMBT1 MNAT1 MCM3
EPHB4 HOXA9 LCN2 HCFC1 PIK3R2
NEDD8 MYBPC3

Proteins with a High Potential Match (3)

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GRB10 DISC1 ABCC6

Created (12)

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ICAM3 NOTCH4 JUNB DOK1 CYB5R3
DMBT1 MNAT1 MCM3 HOXA9 LCN2
PIK3R2 NEDD8

Manual Inspection (Page not found) (13)

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ITGB5 GRB10 MDM4 GNAO1 HLA-DMB
PSMA6 RBPJ PRKAA1 DISC1 ABCC6
EPHB4 HCFC1 MYBPC3


Protein Status Grid - Date: 20:51, 8 November 2007 (UTC)

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HUGO Symbol Action Summary Target page(s) WP Symbol Search
ICAM3 Created Other Pages: Intercellular adhesion molecule 3 (No Data); ICAM3 (No Data); CD50 (No Data); Cd50 (No Data); CDW50 (No Data); Cdw50 (No Data); ICAM-R (No Data); Icam-r (No Data); [1]
NOTCH4 Created Other Pages: Notch homolog 4 (No Data); NOTCH4 (No Data); NOTCH3 (No Data); Notch3 (No Data); FLJ16302 (No Data); Flj16302 (No Data); INT3 (No Data); Int3 (No Data); MGC74442 (No Data); Mgc74442 (No Data); [2]
ITGB5 Manual Inspection (Page not found) Other Pages: Integrin (Unknown Data); ITGB5 (No Data); FLJ26658 (No Data); Flj26658 (No Data); [3]
GRB10 Manual Inspection (Page not found) Other Pages: Growth factor receptor-bound protein 10 (No Data); GRB10 (Protein Template); GRB-IR (No Data); Grb-ir (No Data); IRBP (Redirect -> Iron-responsive element binding protein); Irbp (No Data); KIAA0207 (No Data); Kiaa0207 (No Data); MEG1 (No Data); Meg1 (No Data); RSS (Unknown Data); Rss (Redirect -> RSS); Iron-responsive element binding protein (Protein Template); [4]
MDM4 Manual Inspection (Page not found) Other Pages: Mdm4 (No Data); MDM4 (No Data); DKFZp781B1423 (No Data); Dkfzp781b1423 (No Data); MDMX (Unknown Data); Mdmx (No Data); MGC132766 (No Data); Mgc132766 (No Data); MRP1 (No Data); Mrp1 (No Data); [5]
JUNB Created Other Pages: Jun B proto-oncogene (No Data); JUNB (No Data); [6]
GNAO1 Manual Inspection (Page not found) Other Pages: Guanine nucleotide binding protein (Redirect -> G protein); GNAO1 (No Data); DKFZp686O0962 (No Data); Dkfzp686o0962 (No Data); G-ALPHA-o (No Data); G-alpha-o (No Data); GNAO (No Data); Gnao (No Data); G protein (Unknown Data); [7]
HLA-DMB Manual Inspection (Page not found) Other Pages: Major histocompatibility complex (Unknown Data); HLA-DMB (No Data); D6S221E (No Data); D6s221e (No Data); RING7 (No Data); Ring7 (No Data); [8]
PSMA6 Manual Inspection (Page not found) Other Pages: Proteasome subunit (No Data); PSMA6 (No Data); IOTA (Redirect -> International Occultation Timing Association); Iota (Unknown Data); MGC22756 (No Data); Mgc22756 (No Data); MGC2333 (No Data); Mgc2333 (No Data); MGC23846 (No Data); Mgc23846 (No Data); PROS27 (No Data); Pros27 (No Data); P27K (No Data); P27k (No Data); International Occultation Timing Association (Unknown Data); [9]
DOK1 Created Other Pages: Docking protein 1 (No Data); DOK1 (No Data); MGC117395 (No Data); Mgc117395 (No Data); MGC138860 (No Data); Mgc138860 (No Data); P62DOK (No Data); P62dok (No Data); [10]
RBPJ Manual Inspection (Page not found) Other Pages: Recombination signal binding protein for immunoglobulin kappa J region (No Data); RBPJ (No Data); CBF1 (No Data); Cbf1 (No Data); IGKJRB (No Data); Igkjrb (No Data); IGKJRB1 (No Data); Igkjrb1 (No Data); KBF2 (No Data); Kbf2 (No Data); MGC61669 (No Data); Mgc61669 (No Data); RBP-J (No Data); Rbp-j (No Data); RBPJK (No Data); Rbpjk (No Data); RBPSUH (No Data); Rbpsuh (No Data); SUH (No Data); Suh (No Data); Csl (Redirect -> Columbia School of Linguistics); Columbia School of Linguistics (Unknown Data); [11]
CYB5R3 Created Other Pages: Cytochrome b5 reductase 3 (No Data); CYB5R3 (No Data); B5R (No Data); B5r (No Data); DIA1 (No Data); Dia1 (No Data); [12]
PRKAA1 Manual Inspection (Page not found) Other Pages: Protein kinase (Unknown Data); PRKAA1 (No Data); AMPK (Redirect -> AMP-activated protein kinase); Ampk (No Data); AMPKa1 (No Data); Ampka1 (No Data); MGC33776 (No Data); Mgc33776 (No Data); MGC57364 (No Data); Mgc57364 (No Data); AMP-activated protein kinase (Unknown Data); [13]
DMBT1 Created Other Pages: Deleted in malignant brain tumors 1 (No Data); DMBT1 (No Data); GP340 (No Data); Gp340 (No Data); Muclin (No Data); [14]
DISC1 Manual Inspection (Page not found) Other Pages: Disrupted in schizophrenia 1 (No Data); DISC1 (Protein Template); SCZD9 (No Data); Sczd9 (No Data); KIAA0457 (No Data); Kiaa0457 (No Data); [15]
MNAT1 Created Other Pages: Menage a trois homolog 1 (No Data); MNAT1 (No Data); MAT1 (No Data); Mat1 (No Data); RNF66 (No Data); Rnf66 (No Data); [16]
MCM3 Created Other Pages: MCM3 minichromosome maintenance deficient 3 (No Data); MCM3 (No Data); HCC5 (No Data); Hcc5 (No Data); MGC1157 (No Data); Mgc1157 (No Data); P1-MCM3 (No Data); P1-mcm3 (No Data); P1.h (No Data); RLFB (No Data); Rlfb (No Data); [17]
ABCC6 Manual Inspection (Page not found) Other Pages: ATP-binding cassette (Redirect -> ATP-binding cassette transporter); ABCC6 (Protein Template); ABC34 (No Data); Abc34 (No Data); ARA (DisAmbig); Ara (Redirect -> ARA); EST349056 (No Data); Est349056 (No Data); MLP1 (No Data); Mlp1 (No Data); MOATE (No Data); Moate (Unknown Data); MRP6 (No Data); Mrp6 (No Data); PXE (DisAmbig); Pxe (Redirect -> PXE); PXE1 (No Data); Pxe1 (No Data); ATP-binding cassette transporter (Unknown Data); [18]
EPHB4 Manual Inspection (Page not found) Other Pages: EPH receptor B4 (No Data); EPHB4 (No Data); HTK (DisAmbig); Htk (No Data); MYK1 (No Data); Myk1 (No Data); TYRO11 (No Data); Tyro11 (No Data); [19]
HOXA9 Created Other Pages: Homeobox A9 (No Data); HOXA9 (No Data); HOX1 (No Data); Hox1 (No Data); ABD-B (No Data); Abd-b (No Data); HOX1.7 (No Data); Hox1.7 (No Data); HOX1G (No Data); Hox1g (No Data); MGC1934 (No Data); Mgc1934 (No Data); [20]
LCN2 Created Other Pages: Lipocalin 2 (No Data); LCN2 (No Data); NGAL (No Data); Ngal (No Data); [21]
HCFC1 Manual Inspection (Page not found) Other Pages: Host cell factor C1 (No Data); HCFC1 (No Data); CFF (DisAmbig); Cff (No Data); HCF-1 (No Data); Hcf-1 (No Data); HCF1 (No Data); Hcf1 (No Data); HFC1 (No Data); Hfc1 (No Data); MGC70925 (No Data); Mgc70925 (No Data); VCAF (No Data); Vcaf (No Data); [22]
PIK3R2 Created Other Pages: Phosphoinositide-3-kinase (Redirect -> PIK3R1); PIK3R2 (No Data); P85B (No Data); P85b (No Data); P85-BETA (No Data); P85-beta (No Data); PIK3R1 (Codes Found, but no match[skip]); [23]
NEDD8 Created Other Pages: Neural precursor cell expressed (No Data); NEDD8 (No Data); MGC104393 (No Data); Mgc104393 (No Data); MGC125896 (No Data); Mgc125896 (No Data); MGC125897 (No Data); Mgc125897 (No Data); Nedd-8 (No Data); [24]
MYBPC3 Manual Inspection (Page not found) Other Pages: Myosin binding protein C (No Data); MYBPC3 (No Data); FHC (DisAmbig); Fhc (No Data); CMH4 (No Data); Cmh4 (No Data); MYBP-C (No Data); Mybp-c (No Data); [25]

Vebose Log - Date: 20:51, 8 November 2007 (UTC)

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ABCC6

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  • INFO: Beginning work on ABCC6... {November 8, 2007 12:18:52 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 12:19:20 PM PST} 
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = ATP-binding cassette, sub-family C (CFTR/MRP), member 6
 | HGNCid = 57
 | Symbol = ABCC6
 | AltSymbols =; ABC34; ARA; EST349056; MLP1; MOATE; MRP6; PXE; PXE1
 | OMIM = 603234
 | ECnumber =  
 | Homologene = 55559
 | MGIid = 1351634
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0042626 |text = ATPase activity, coupled to transmembrane movement of substances}} 
 | Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} 
 | Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0042493 |text = response to drug}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 368
    | Hs_Ensembl =  
    | Hs_RefseqProtein = XP_001125860
    | Hs_RefseqmRNA = XM_001125860
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr =  
    | Hs_GenLoc_start =  
    | Hs_GenLoc_end =  
    | Hs_Uniprot =  
    | Mm_EntrezGene = 27421
    | Mm_Ensembl = ENSMUSG00000030834
    | Mm_RefseqmRNA = NM_018795
    | Mm_RefseqProtein = NP_061265
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 45844422
    | Mm_GenLoc_end = 45898328
    | Mm_Uniprot = Q9R1S7
  }}
}}
'''ATP-binding cassette, sub-family C (CFTR/MRP), member 6''', also known as '''ABCC6''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene.<ref>{{cite web | title = Entrez Gene: ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=368| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Uitto J, Pulkkinen L, Ringpfeil F |title=Molecular genetics of pseudoxanthoma elasticum: a metabolic disorder at the environment-genome interface? |journal=Trends in molecular medicine |volume=7 |issue= 1 |pages= 13-7 |year= 2001 |pmid= 11427982 |doi=  }}
*{{cite journal  | author=Hu X, Plomp AS, van Soest S, ''et al.'' |title=Pseudoxanthoma elasticum: a clinical, histopathological, and molecular update. |journal=Survey of ophthalmology |volume=48 |issue= 4 |pages= 424-38 |year= 2003 |pmid= 12850230 |doi=  }}
*{{cite journal  | author=Chassaing N, Martin L, Calvas P, ''et al.'' |title=Pseudoxanthoma elasticum: a clinical, pathophysiological and genetic update including 11 novel ABCC6 mutations. |journal=J. Med. Genet. |volume=42 |issue= 12 |pages= 881-92 |year= 2006 |pmid= 15894595 |doi= 10.1136/jmg.2004.030171 }}
*{{cite journal  | author=Uitto J |title=The gene family of ABC transporters--novel mutations, new phenotypes. |journal=Trends in molecular medicine |volume=11 |issue= 8 |pages= 341-3 |year= 2005 |pmid= 15996518 |doi= 10.1016/j.molmed.2005.06.004 }}
}}
{{refend}}

{{protein-stub}}

CYB5R3

[edit]
  • INFO: Beginning work on CYB5R3... {November 8, 2007 12:19:20 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein CYB5R3 image.jpg {November 8, 2007 12:19:53 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 12:20:06 PM PST}
  • CREATED: Created new protein page: CYB5R3 {November 8, 2007 12:20:13 PM PST}

DISC1

[edit]
  • INFO: Beginning work on DISC1... {November 8, 2007 12:41:52 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 12:42:44 PM PST} 
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Disrupted in schizophrenia 1
 | HGNCid = 2888
 | Symbol = DISC1
 | AltSymbols =; SCZD9; KIAA0457
 | OMIM = 605210
 | ECnumber =  
 | Homologene = 10257
 | MGIid = 2447658
 | GeneAtlas_image1 = PBB_GE_DISC1_206090_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_DISC1_207759_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} 
 | Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005874 |text = microtubule}} 
 | Process = {{GNF_GO|id=GO:0008150 |text = biological_process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 27185
    | Hs_Ensembl = ENSG00000162946
    | Hs_RefseqProtein = NP_001012975
    | Hs_RefseqmRNA = NM_001012957
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 229829184
    | Hs_GenLoc_end = 230243641
    | Hs_Uniprot = Q9NRI5
    | Mm_EntrezGene = 244667
    | Mm_Ensembl =  
    | Mm_RefseqmRNA = NM_170596
    | Mm_RefseqProtein = NP_733484
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''Disrupted in schizophrenia 1''', also known as '''DISC1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref>{{cite web | title = Entrez Gene: DISC1 disrupted in schizophrenia 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27185| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Blackwood DH, Muir WJ |title=Clinical phenotypes associated with DISC1, a candidate gene for schizophrenia. |journal=Neurotoxicity research |volume=6 |issue= 1 |pages= 35-41 |year= 2004 |pmid= 15184103 |doi=  }}
*{{cite journal  | author=Millar JK, James R, Brandon NJ, Thomson PA |title=DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness. |journal=Ann. Med. |volume=36 |issue= 5 |pages= 367-78 |year= 2005 |pmid= 15478311 |doi=  }}
*{{cite journal  | author=Porteous DJ, Thomson P, Brandon NJ, Millar JK |title=The genetics and biology of DISC1--an emerging role in psychosis and cognition. |journal=Biol. Psychiatry |volume=60 |issue= 2 |pages= 123-31 |year= 2006 |pmid= 16843095 |doi= 10.1016/j.biopsych.2006.04.008 }}
*{{cite journal  | author=Lipska BK, Mitkus SN, Mathew SV, ''et al.'' |title=Functional genomics in postmortem human brain: abnormalities in a DISC1 molecular pathway in schizophrenia. |journal=Dialogues in clinical neuroscience |volume=8 |issue= 3 |pages= 353-7 |year= 2006 |pmid= 17117617 |doi=  }}
}}
{{refend}}

{{protein-stub}}

DMBT1

[edit]
  • INFO: Beginning work on DMBT1... {November 8, 2007 12:20:13 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 12:20:47 PM PST}
  • CREATED: Created new protein page: DMBT1 {November 8, 2007 12:20:54 PM PST}

DOK1

[edit]
  • INFO: Beginning work on DOK1... {November 8, 2007 12:20:54 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 12:21:11 PM PST}
  • CREATED: Created new protein page: DOK1 {November 8, 2007 12:21:19 PM PST}

EPHB4

[edit]
  • INFO: Beginning work on EPHB4... {November 8, 2007 12:21:19 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein EPHB4 image.jpg {November 8, 2007 12:22:10 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 12:22:24 PM PST} 
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_EPHB4_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2bba.
 | PDB = {{PDB2|2bba}}, {{PDB2|2hle}}
 | Name = EPH receptor B4
 | HGNCid = 3395
 | Symbol = EPHB4
 | AltSymbols =; HTK; MYK1; TYRO11
 | OMIM = 600011
 | ECnumber =  
 | Homologene = 20939
 | MGIid = 104757
 | GeneAtlas_image1 = PBB_GE_EPHB4_202894_at_tn.png
 | GeneAtlas_image2 = PBB_GE_EPHB4_216680_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005003 |text = ephrin receptor activity}} {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008046 |text = axon guidance receptor activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} 
 | Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} 
 | Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0007411 |text = axon guidance}} {{GNF_GO|id=GO:0007612 |text = learning}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0045765 |text = regulation of angiogenesis}} {{GNF_GO|id=GO:0048168 |text = regulation of neuronal synaptic plasticity}} {{GNF_GO|id=GO:0048170 |text = positive regulation of long-term neuronal synaptic plasticity}} {{GNF_GO|id=GO:0050770 |text = regulation of axonogenesis}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2050
    | Hs_Ensembl = ENSG00000196411
    | Hs_RefseqProtein = NP_004435
    | Hs_RefseqmRNA = NM_004444
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 100238123
    | Hs_GenLoc_end = 100263079
    | Hs_Uniprot = P54760
    | Mm_EntrezGene = 13846
    | Mm_Ensembl = ENSMUSG00000029710
    | Mm_RefseqmRNA = NM_010144
    | Mm_RefseqProtein = NP_034274
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 137579897
    | Mm_GenLoc_end = 137604298
    | Mm_Uniprot = Q3V1K8
  }}
}}
'''EPH receptor B4''', also known as '''EPHB4''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.<ref>{{cite web | title = Entrez Gene: EPHB4 EPH receptor B4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2050| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Flanagan JG, Vanderhaeghen P |title=The ephrins and Eph receptors in neural development. |journal=Annu. Rev. Neurosci. |volume=21 |issue=  |pages= 309-45 |year= 1998 |pmid= 9530499 |doi= 10.1146/annurev.neuro.21.1.309 }}
*{{cite journal  | author=Zhou R |title=The Eph family receptors and ligands. |journal=Pharmacol. Ther. |volume=77 |issue= 3 |pages= 151-81 |year= 1998 |pmid= 9576626 |doi=  }}
*{{cite journal  | author=Holder N, Klein R |title=Eph receptors and ephrins: effectors of morphogenesis. |journal=Development |volume=126 |issue= 10 |pages= 2033-44 |year= 1999 |pmid= 10207129 |doi=  }}
*{{cite journal  | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |issue=  |pages= 177-244 |year= 2000 |pmid= 10730216 |doi=  }}
*{{cite journal  | author=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=355 |issue= 1399 |pages= 993-1002 |year= 2001 |pmid= 11128993 |doi= 10.1098/rstb.2000.0635 }}
*{{cite journal  | author=Wilkinson DG |title=Multiple roles of EPH receptors and ephrins in neural development. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 155-64 |year= 2001 |pmid= 11256076 |doi=  }}
}}
{{refend}}

{{protein-stub}}

GNAO1

[edit]
  • INFO: Beginning work on GNAO1... {November 8, 2007 12:22:24 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 12:23:45 PM PST} 
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
 | HGNCid = 4389
 | Symbol = GNAO1
 | AltSymbols =; DKFZp686O0962; G-ALPHA-o; GNAO
 | OMIM = 139311
 | ECnumber =  
 | Homologene = 39203
 | MGIid = 95775
 | GeneAtlas_image1 = PBB_GE_GNAO1_204762_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_GNAO1_204763_s_at_tn.png
 | GeneAtlas_image3 = PBB_GE_GNAO1_215912_at_tn.png
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005057 |text = receptor signaling protein activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}} 
 | Component = 
 | Process = {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007212 |text = dopamine receptor signaling pathway}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007411 |text = axon guidance}} {{GNF_GO|id=GO:0007626 |text = locomotory behavior}} {{GNF_GO|id=GO:0008016 |text = regulation of heart contraction}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2775
    | Hs_Ensembl = ENSG00000087258
    | Hs_RefseqProtein = NP_066268
    | Hs_RefseqmRNA = NM_020988
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 54783389
    | Hs_GenLoc_end = 54948651
    | Hs_Uniprot = P09471
    | Mm_EntrezGene = 14681
    | Mm_Ensembl = ENSMUSG00000031748
    | Mm_RefseqmRNA = NM_010308
    | Mm_RefseqProtein = NP_034438
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 96699967
    | Mm_GenLoc_end = 96858351
    | Mm_Uniprot = Q543S2
  }}
}}
'''Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O''', also known as '''GNAO1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = 
}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Raymond JR, Mukhin YV, Gelasco A, ''et al.'' |title=Multiplicity of mechanisms of serotonin receptor signal transduction. |journal=Pharmacol. Ther. |volume=92 |issue= 2-3 |pages= 179-212 |year= 2002 |pmid= 11916537 |doi=  }}
}}
{{refend}}

{{protein-stub}}

GRB10

[edit]
  • INFO: Beginning work on GRB10... {November 8, 2007 12:23:45 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein GRB10 image.jpg {November 8, 2007 12:24:59 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 12:25:36 PM PST} 
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_GRB10_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1nrv.
 | PDB = {{PDB2|1nrv}}
 | Name = Growth factor receptor-bound protein 10
 | HGNCid = 4564
 | Symbol = GRB10
 | AltSymbols =; GRB-IR; IRBP; KIAA0207; MEG1; RSS
 | OMIM = 601523
 | ECnumber =  
 | Homologene = 3882
 | MGIid = 103232
 | GeneAtlas_image1 = PBB_GE_GRB10_209409_at_tn.png
 | GeneAtlas_image2 = PBB_GE_GRB10_209410_s_at_tn.png
 | GeneAtlas_image3 = PBB_GE_GRB10_210999_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0005070 |text = SH3/SH2 adaptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} 
 | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} 
 | Process = {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0008286 |text = insulin receptor signaling pathway}} {{GNF_GO|id=GO:0048009 |text = insulin-like growth factor receptor signaling pathway}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2887
    | Hs_Ensembl = ENSG00000106070
    | Hs_RefseqProtein = NP_001001549
    | Hs_RefseqmRNA = NM_001001549
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 50625260
    | Hs_GenLoc_end = 50828652
    | Hs_Uniprot = Q13322
    | Mm_EntrezGene = 14783
    | Mm_Ensembl = ENSMUSG00000020176
    | Mm_RefseqmRNA = NM_010345
    | Mm_RefseqProtein = NP_034475
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 11830511
    | Mm_GenLoc_end = 11937390
    | Mm_Uniprot = Q3TFU9
  }}
}}
'''Growth factor receptor-bound protein 10''', also known as '''GRB10''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref>{{cite web | title = Entrez Gene: GRB10 growth factor receptor-bound protein 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2887| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}

HCFC1

[edit]
  • INFO: Beginning work on HCFC1... {November 8, 2007 12:25:36 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 12:26:34 PM PST} 
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Host cell factor C1 (VP16-accessory protein)
 | HGNCid = 4839
 | Symbol = HCFC1
 | AltSymbols =; CFF; HCF-1; HCF1; HFC1; MGC70925; VCAF
 | OMIM = 300019
 | ECnumber =  
 | Homologene = 3898
 | MGIid = 105942
 | GeneAtlas_image1 = PBB_GE_HCFC1_202474_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_HCFC1_202473_x_at_tn.png
 | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} 
 | Process = {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0019046 |text = reactivation of latent virus}} {{GNF_GO|id=GO:0043254 |text = regulation of protein complex assembly}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}} {{GNF_GO|id=GO:0045787 |text = positive regulation of progression through cell cycle}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3054
    | Hs_Ensembl = ENSG00000172534
    | Hs_RefseqProtein = NP_005325
    | Hs_RefseqmRNA = NM_005334
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 152866198
    | Hs_GenLoc_end = 152890452
    | Hs_Uniprot = P51610
    | Mm_EntrezGene = 15161
    | Mm_Ensembl = ENSMUSG00000031386
    | Mm_RefseqmRNA = NM_008224
    | Mm_RefseqProtein = NP_032250
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 70195515
    | Mm_GenLoc_end = 70219035
    | Mm_Uniprot = Q3USQ6
  }}
}}
'''Host cell factor C1 (VP16-accessory protein)''', also known as '''HCFC1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.<ref>{{cite web | title = Entrez Gene: HCFC1 host cell factor C1 (VP16-accessory protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3054| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}

HLA-DMB

[edit]
  • INFO: Beginning work on HLA-DMB... {November 8, 2007 12:26:34 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein HLA-DMB image.jpg {November 8, 2007 12:27:08 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 12:27:26 PM PST} 
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_HLA-DMB_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hdm.
 | PDB = {{PDB2|1hdm}}, {{PDB2|2bc4}}
 | Name = Major histocompatibility complex, class II, DM beta
 | HGNCid = 4935
 | Symbol = HLA-DMB
 | AltSymbols =; D6S221E; RING7
 | OMIM = 142856
 | ECnumber =  
 | Homologene = 68231
 | MGIid = 95922
 | GeneAtlas_image1 = PBB_GE_HLA-DMB_203932_at_tn.png
 | Function = 
 | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042613 |text = MHC class II protein complex}} 
 | Process = {{GNF_GO|id=GO:0002504 |text = antigen processing and presentation of peptide or polysaccharide antigen via MHC class II}} {{GNF_GO|id=GO:0006955 |text = immune response}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3109
    | Hs_Ensembl = ENSG00000206294
    | Hs_RefseqProtein = NP_002109
    | Hs_RefseqmRNA = NM_002118
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = c6_QBL
    | Hs_GenLoc_start = 32973998
    | Hs_GenLoc_end = 32980399
    | Hs_Uniprot = P28068
    | Mm_EntrezGene = 14999
    | Mm_Ensembl =  
    | Mm_RefseqmRNA = NM_010387
    | Mm_RefseqProtein = NP_034517
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''Major histocompatibility complex, class II, DM beta''', also known as '''HLA-DMB''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.<ref>{{cite web | title = Entrez Gene: HLA-DMB major histocompatibility complex, class II, DM beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3109| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Vogt AB, Kropshofer H |title=HLA-DM - an endosomal and lysosomal chaperone for the immune system. |journal=Trends Biochem. Sci. |volume=24 |issue= 4 |pages= 150-4 |year= 1999 |pmid= 10322421 |doi=  }}
*{{cite journal  | author=Kropshofer H, Hämmerling GJ, Vogt AB |title=The impact of the non-classical MHC proteins HLA-DM and HLA-DO on loading of MHC class II molecules. |journal=Immunol. Rev. |volume=172 |issue=  |pages= 267-78 |year= 2000 |pmid= 10631952 |doi=  }}
}}
{{refend}}

{{protein-stub}}

HOXA9

[edit]
  • INFO: Beginning work on HOXA9... {November 8, 2007 12:27:26 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein HOXA9 image.jpg {November 8, 2007 12:28:16 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 12:28:58 PM PST}
  • CREATED: Created new protein page: HOXA9 {November 8, 2007 12:29:05 PM PST}

ICAM3

[edit]
  • INFO: Beginning work on ICAM3... {November 8, 2007 12:29:05 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein ICAM3 image.jpg {November 8, 2007 12:29:38 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 12:29:52 PM PST}
  • CREATED: Created new protein page: ICAM3 {November 8, 2007 12:30:00 PM PST}

ITGB5

[edit]
  • INFO: Beginning work on ITGB5... {November 8, 2007 12:31:10 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 12:32:20 PM PST} 
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Integrin, beta 5
 | HGNCid = 6160
 | Symbol = ITGB5
 | AltSymbols =; FLJ26658
 | OMIM = 147561
 | ECnumber =  
 | Homologene = 20511
 | MGIid = 96614
 | GeneAtlas_image1 = PBB_GE_ITGB5_201124_at_tn.png
 | GeneAtlas_image2 = PBB_GE_ITGB5_201125_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005178 |text = integrin binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} 
 | Component = {{GNF_GO|id=GO:0008305 |text = integrin complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} 
 | Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007160 |text = cell-matrix adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3693
    | Hs_Ensembl = ENSG00000082781
    | Hs_RefseqProtein = XP_001129224
    | Hs_RefseqmRNA = XM_001129224
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 125964488
    | Hs_GenLoc_end = 126088842
    | Hs_Uniprot = P18084
    | Mm_EntrezGene = 16419
    | Mm_Ensembl = ENSMUSG00000022817
    | Mm_RefseqmRNA = NM_010580
    | Mm_RefseqProtein = NP_034710
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 33749412
    | Mm_GenLoc_end = 33868892
    | Mm_Uniprot = Q6PE70
  }}
}}
'''Integrin, beta 5''', also known as '''ITGB5''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = 
}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Evans JP |title=Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization. |journal=Bioessays |volume=23 |issue= 7 |pages= 628-39 |year= 2001 |pmid= 11462216 |doi= 10.1002/bies.1088 }}
}}
{{refend}}

{{protein-stub}}

JUNB

[edit]
  • INFO: Beginning work on JUNB... {November 8, 2007 12:32:20 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 12:32:49 PM PST}
  • CREATED: Created new protein page: JUNB {November 8, 2007 12:32:56 PM PST}

LCN2

[edit]
  • INFO: Beginning work on LCN2... {November 8, 2007 12:32:56 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein LCN2 image.jpg {November 8, 2007 12:33:28 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 12:33:38 PM PST}
  • CREATED: Created new protein page: LCN2 {November 8, 2007 12:33:45 PM PST}

MCM3

[edit]
  • INFO: Beginning work on MCM3... {November 8, 2007 12:33:45 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 12:34:44 PM PST}
  • CREATED: Created new protein page: MCM3 {November 8, 2007 12:34:51 PM PST}

MDM4

[edit]
  • INFO: Beginning work on MDM4... {November 8, 2007 12:34:51 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein MDM4 image.jpg {November 8, 2007 12:35:28 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 12:35:46 PM PST} 
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_MDM4_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2cr8.
 | PDB = {{PDB2|2cr8}}
 | Name = Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)
 | HGNCid = 6974
 | Symbol = MDM4
 | AltSymbols =; DKFZp781B1423; MDMX; MGC132766; MRP1
 | OMIM = 602704
 | ECnumber =  
 | Homologene = 1794
 | MGIid = 107934
 | GeneAtlas_image1 = PBB_GE_MDM4_205655_at_tn.png
 | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} 
 | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} 
 | Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0042177 |text = negative regulation of protein catabolic process}} {{GNF_GO|id=GO:0045023 |text = G0 to G1 transition}} {{GNF_GO|id=GO:0050821 |text = protein stabilization}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4194
    | Hs_Ensembl = ENSG00000198625
    | Hs_RefseqProtein = NP_002384
    | Hs_RefseqmRNA = NM_002393
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 202752134
    | Hs_GenLoc_end = 202793871
    | Hs_Uniprot = O15151
    | Mm_EntrezGene = 17248
    | Mm_Ensembl =  
    | Mm_RefseqmRNA = NM_008575
    | Mm_RefseqProtein = NP_032601
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr =  
    | Mm_GenLoc_start =  
    | Mm_GenLoc_end =  
    | Mm_Uniprot =  
  }}
}}
'''Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)''', also known as '''MDM4''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2<ref>{{cite web | title = Entrez Gene: MDM4 Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4194| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Meulmeester E, Pereg Y, Shiloh Y, Jochemsen AG |title=ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation. |journal=Cell Cycle |volume=4 |issue= 9 |pages= 1166-70 |year= 2006 |pmid= 16082221 |doi=  }}
}}
{{refend}}

{{protein-stub}}

MNAT1

[edit]
  • INFO: Beginning work on MNAT1... {November 8, 2007 12:35:46 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein MNAT1 image.jpg {November 8, 2007 12:36:21 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 12:36:33 PM PST}
  • CREATED: Created new protein page: MNAT1 {November 8, 2007 12:36:42 PM PST}

MYBPC3

[edit]
  • INFO: Beginning work on MYBPC3... {November 8, 2007 12:36:42 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein MYBPC3 image.jpg {November 8, 2007 12:37:16 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 12:37:30 PM PST} 
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_MYBPC3_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gxe.
 | PDB = {{PDB2|1gxe}}, {{PDB2|1pd6}}, {{PDB2|2avg}}
 | Name = Myosin binding protein C, cardiac
 | HGNCid = 7551
 | Symbol = MYBPC3
 | AltSymbols =; FHC; CMH4; MYBP-C
 | OMIM = 600958
 | ECnumber =  
 | Homologene = 215
 | MGIid = 102844
 | GeneAtlas_image1 = PBB_GE_MYBPC3_208040_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008307 |text = structural constituent of muscle}} 
 | Component = {{GNF_GO|id=GO:0005863 |text = striated muscle thick filament}} {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}} 
 | Process = {{GNF_GO|id=GO:0006942 |text = regulation of striated muscle contraction}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0055010 |text = ventricular cardiac muscle morphogenesis}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4607
    | Hs_Ensembl = ENSG00000134571
    | Hs_RefseqProtein = NP_000247
    | Hs_RefseqmRNA = NM_000256
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 47309527
    | Hs_GenLoc_end = 47330806
    | Hs_Uniprot = Q14896
    | Mm_EntrezGene = 17868
    | Mm_Ensembl = ENSMUSG00000002100
    | Mm_RefseqmRNA = NM_008653
    | Mm_RefseqProtein = NP_032679
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 90918983
    | Mm_GenLoc_end = 90937350
    | Mm_Uniprot = Q3TF37
  }}
}}
'''Myosin binding protein C, cardiac''', also known as '''MYBPC3''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy.<ref>{{cite web | title = Entrez Gene: MYBPC3 myosin binding protein C, cardiac| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4607| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Vikstrom KL, Leinwand LA |title=Contractile protein mutations and heart disease. |journal=Curr. Opin. Cell Biol. |volume=8 |issue= 1 |pages= 97-105 |year= 1996 |pmid= 8791411 |doi=  }}
*{{cite journal  | author=Schaub MC, Hefti MA, Zuellig RA, Morano I |title=Modulation of contractility in human cardiac hypertrophy by myosin essential light chain isoforms. |journal=Cardiovasc. Res. |volume=37 |issue= 2 |pages= 381-404 |year= 1998 |pmid= 9614495 |doi=  }}
*{{cite journal  | author=Bonne G, Carrier L, Richard P, ''et al.'' |title=Familial hypertrophic cardiomyopathy: from mutations to functional defects. |journal=Circ. Res. |volume=83 |issue= 6 |pages= 580-93 |year= 1998 |pmid= 9742053 |doi=  }}
*{{cite journal  | author=Jääskeläinen P, Miettinen R, Kärkkäinen P, ''et al.'' |title=Genetics of hypertrophic cardiomyopathy in eastern Finland: few founder mutations with benign or intermediary phenotypes. |journal=Ann. Med. |volume=36 |issue= 1 |pages= 23-32 |year= 2004 |pmid= 15000344 |doi=  }}
}}
{{refend}}

{{protein-stub}}

NEDD8

[edit]
  • INFO: Beginning work on NEDD8... {November 8, 2007 12:37:30 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein NEDD8 image.jpg {November 8, 2007 12:38:02 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 12:38:17 PM PST}
  • CREATED: Created new protein page: NEDD8 {November 8, 2007 12:38:24 PM PST}

NOTCH4

[edit]
  • INFO: Beginning work on NOTCH4... {November 8, 2007 12:38:25 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 12:38:44 PM PST}
  • CREATED: Created new protein page: NOTCH4 {November 8, 2007 12:38:53 PM PST}

PIK3R2

[edit]
  • INFO: Beginning work on PIK3R2... {November 8, 2007 12:38:53 PM PST}
  • CREATE: Found no pages, creating new page. {November 8, 2007 12:39:47 PM PST}
  • CREATED: Created new protein page: PIK3R2 {November 8, 2007 12:39:55 PM PST}

PRKAA1

[edit]
  • INFO: Beginning work on PRKAA1... {November 8, 2007 12:39:55 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein PRKAA1 image.jpg {November 8, 2007 12:40:39 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 12:40:58 PM PST} 
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_PRKAA1_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2h6d.
 | PDB = {{PDB2|2h6d}}
 | Name = Protein kinase, AMP-activated, alpha 1 catalytic subunit
 | HGNCid = 9376
 | Symbol = PRKAA1
 | AltSymbols =; AMPK; AMPKa1; MGC33776; MGC57364
 | OMIM = 602739
 | ECnumber =  
 | Homologene = 49590
 | MGIid = 2145955
 | GeneAtlas_image1 = PBB_GE_PRKAA1_209799_at_tn.png
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004691 |text = cAMP-dependent protein kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0042557 |text = eukaryotic elongation factor-2 kinase activator activity}} 
 | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} 
 | Process = {{GNF_GO|id=GO:0000187 |text = activation of MAPK activity}} {{GNF_GO|id=GO:0001666 |text = response to hypoxia}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006633 |text = fatty acid biosynthetic process}} {{GNF_GO|id=GO:0006695 |text = cholesterol biosynthetic process}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0017148 |text = negative regulation of protein biosynthetic process}} {{GNF_GO|id=GO:0045542 |text = positive regulation of cholesterol biosynthetic process}} {{GNF_GO|id=GO:0045722 |text = positive regulation of gluconeogenesis}} {{GNF_GO|id=GO:0045768 |text = positive regulation of anti-apoptosis}} {{GNF_GO|id=GO:0046318 |text = negative regulation of glucosylceramide biosynthetic process}} {{GNF_GO|id=GO:0046321 |text = positive regulation of fatty acid oxidation}} {{GNF_GO|id=GO:0046326 |text = positive regulation of glucose import}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5562
    | Hs_Ensembl = ENSG00000132356
    | Hs_RefseqProtein = NP_006242
    | Hs_RefseqmRNA = NM_006251
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 40795239
    | Hs_GenLoc_end = 40834046
    | Hs_Uniprot = Q13131
    | Mm_EntrezGene = 105787
    | Mm_Ensembl = ENSMUSG00000050697
    | Mm_RefseqmRNA = XM_973840
    | Mm_RefseqProtein = XP_978934
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 5091090
    | Mm_GenLoc_end = 5129114
    | Mm_Uniprot = Q3TUQ7
  }}
}}
'''Protein kinase, AMP-activated, alpha 1 catalytic subunit''', also known as '''PRKAA1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.<ref>{{cite web | title = Entrez Gene: PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5562| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}

PSMA6

[edit]
  • INFO: Beginning work on PSMA6... {November 8, 2007 12:40:58 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein PSMA6 image.jpg {November 8, 2007 12:41:31 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 12:41:52 PM PST} 
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_PSMA6_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1iru.
 | PDB = {{PDB2|1iru}}
 | Name = Proteasome (prosome, macropain) subunit, alpha type, 6
 | HGNCid = 9535
 | Symbol = PSMA6
 | AltSymbols =; IOTA; MGC22756; MGC2333; MGC23846; PROS27; p27K
 | OMIM = 602855
 | ECnumber =  
 | Homologene = 2085
 | MGIid = 1347006
 | GeneAtlas_image1 = PBB_GE_PSMA6_208805_at_tn.png
 | Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0004298 |text = threonine endopeptidase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} 
 | Component = {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005839 |text = proteasome core complex (sensu Eukaryota)}} 
 | Process = {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5687
    | Hs_Ensembl = ENSG00000100902
    | Hs_RefseqProtein = NP_002782
    | Hs_RefseqmRNA = NM_002791
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 34831314
    | Hs_GenLoc_end = 34856431
    | Hs_Uniprot = P60900
    | Mm_EntrezGene = 26443
    | Mm_Ensembl = ENSMUSG00000021024
    | Mm_RefseqmRNA = NM_011968
    | Mm_RefseqProtein = NP_036098
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 56317018
    | Mm_GenLoc_end = 56336579
    | Mm_Uniprot = Q0VGS3
  }}
}}
'''Proteasome (prosome, macropain) subunit, alpha type, 6''', also known as '''PSMA6''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome.<ref>{{cite web | title = Entrez Gene: PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5687| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue=  |pages= 801-47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101 }}
*{{cite journal  | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi=  }}
}}
{{refend}}

{{protein-stub}}

RBPJ

[edit]
  • INFO: Beginning work on RBPJ... {November 8, 2007 12:30:00 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein RBPJ image.jpg {November 8, 2007 12:30:40 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 12:31:10 PM PST} 
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_RBPJ_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2f8x.
 | PDB = {{PDB2|2f8x}}
 | Name = Recombination signal binding protein for immunoglobulin kappa J region
 | HGNCid = 5724
 | Symbol = RBPJ
 | AltSymbols =; CBF1; IGKJRB; IGKJRB1; KBF2; MGC61669; RBP-J; RBPJK; RBPSUH; SUH; csl
 | OMIM = 147183
 | ECnumber =  
 | Homologene = 7511
 | MGIid = 96522
 | GeneAtlas_image1 = PBB_GE_RBPJ_211974_x_at_tn.png
 | Function = {{GNF_GO|id=GO:0000150 |text = recombinase activity}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}} 
 | Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0001837 |text = epithelial to mesenchymal transition}} {{GNF_GO|id=GO:0006310 |text = DNA recombination}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007219 |text = Notch signaling pathway}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0030097 |text = hemopoiesis}} {{GNF_GO|id=GO:0030183 |text = B cell differentiation}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}} {{GNF_GO|id=GO:0045892 |text = negative regulation of transcription, DNA-dependent}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3516
    | Hs_Ensembl = ENSG00000168214
    | Hs_RefseqProtein = NP_005340
    | Hs_RefseqmRNA = NM_005349
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 25930430
    | Hs_GenLoc_end = 26045851
    | Hs_Uniprot = Q06330
    | Mm_EntrezGene = 19664
    | Mm_Ensembl = ENSMUSG00000039191
    | Mm_RefseqmRNA = NM_001080927
    | Mm_RefseqProtein = NP_001074396
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 53878598
    | Mm_GenLoc_end = 53944383
    | Mm_Uniprot = A0N920
  }}
}}
'''Recombination signal binding protein for immunoglobulin kappa J region''', also known as '''RBPJ''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = 
}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Oka C, Kawaichi M |title=V(D)J recombination of immunoglobulin genes. |journal=Adv. Biophys. |volume=31 |issue=  |pages= 163-80 |year= 1995 |pmid= 7625272 |doi=  }}
}}
{{refend}}

{{protein-stub}}

end log.

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