User:Prof. Dr. Dietmar J. Manstein

Dietmar J. Manstein (born 28 April 1955 in Riegelsberg) is a German biochemist. He heads the Institute of Biophysical Chemistry and the Central Research Facilities for Structural Biochemistry and Laser Microscopy at the Hannover Medical School.

Career

Manstein studied biochemistry at the Leibniz University of Hanover from 1978. After completing his diploma thesis in the laboratory of Jürg P. Rosenbusch at the European Molecular Biology Laboratory (EMBL) in Heidelberg, he worked until 1986 as a doctoral student in the research groups of Emil F. Pai (Department of Biophysics, Max Planck Institute for Medical Research, Heidelberg and Vincent Massey Dept. of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI) on the total synthesis of FAD and FMN analogues and their application to the investigation of the stereospecificity of flavin cofactors in enzymatic reactions. He received his PhD in biochemistry from the University of Heidelberg. His doctoral supervisor was Roger S. Goody FRS.

In 1987, he joined the research group of James A. Spudich at Stanford University School of Medicine (USA) as a postdoctoral fellow. At Stanford, his research focused on the establishment of molecular-genetic methods for the investigation of the model system Dictyostelium discoideum and the first recombinant expression system for the production of functional myosin motors.

In 1990, he joined the National Institute for Medical Research in London as principal investigator in the Department of Physical Biochemistry directed by David Trentham FRS, where he developed and applied molecular genetic, transient kinetic and hybrid structural biology approaches to study the function, structure and regulation of myosin-2 and actomyosin complexes.

In 1996, he and his research group moved to Heidelberg, where he spent the following years at the MPI for Medical Research investigating the basic principles underlying the cellular function of motor proteins and chemomechanical coupling in molecular motors. In the same year, he took on teaching duties in the Faculty of Biology at Ruprecht-Karls-Universität Heidelberg, where in 1999 he was awarded the venia legendi for biochemistry/biophysics.

He served as Executive Editor of the Journal of Muscle Research and Cell Motility from 1992 to 2020 and since 2008 he is Editor of FEBS Letters. In 2011, he was involved in the founding of FEBS Open Bio, an open access journal for the rapid publication of research articles in the field of molecular and cellular biosciences, for which he continues to serve as Editor. He organised and coordinated the programme of numerous international meetings such as the 34th meeting of the European Cytoskeletal Forum - ECF2022 in Hannover and the 49th European Muscle Conference - EMC2022 Prague. From 1996 to 2006, he organised annual international conferences entitled "Molecular Motors and New Microscopy Techniques". These took place in the Max Planck House, Heidelberg (1996-2000), in the Stadthalle Heidelberg (2001), in the conference hotel Maria in der Aue near Cologne (2001), in Schneverdingen (2003), in the Loccum Monastery (2004), in the Elsa Brändström House (2005) and in the HZI Forum in Braunschweig (2006).

In 2002, he was appointed full professor and director of the Institute of Biophysical Chemistry at Hannover Medical School, where he is also head of the central research facilities for structural biochemistry and laser microscopy since 2005. His research at the MHH focusses on cellular function, structure-function relationships and allosteric regulation of motor proteins and cytoskeletal proteins. Manstein is a project leader within the RESIST Cluster of Excellence and a member of the Clinical Conference of the MHH, the MHH Centre for Rare Diseases and the Board of Directors of the Centre for Structural Systems Biology (CSSB), which is lacated on the DERSY campus in Hamburg-Bahrenfeld.

Fonts/Selection

• with J. P. Rosenbusch, J. Berriman, K. Leonard: Ultrastructure of native lipoprotein from Escherichia coli envelopes. In: Journal of Molecular Biology. Band 189, 1986, S. 701–707, doi:10.1016/0022-2836(86)90499-7
• with D. C. Wienke, M. L. W. Knetsch und anderen: Disruption of a dynamin homologue affects endocytosis, organelle morphology and cytokinesis in Dictyostelium discoideum. In: Molecular Biology of the Cell. Band 10, 1999, S. 225–243, doi:10.1091/mbc.10.1.225
• with Derek Toomre: Lighting up the cell surface with evanescent wave microscopy. In: Trends in Cell Biology. Band 11, 2001, S. 298–303, doi:10.1016/S0962-8924(01)02027-X
• with C. Ruff, M Furch, B. Brenner E. Meyhöfer und anderen: Single-molecule tracking of myosins with genetically engineered amplifier domains. In: Nature Structural & Molecular Biology. Band 8, 2001, S. 226–229, doi:10.1038/84962
• with H. H. Niemann, M. L. W. Knetsch, F. J. Kull und anderen: Crystal structure of a dynamin GTPase domain in both nucleotide-free and GDP-bound forms. In: The EMBO Journal. Band 21, 2001, S. 5813–5821, doi:10.1093/emboj/20.21.5813
• with Sarah M. Heissler: Nonmuscle myosin-2: mix and match. In: Cellular and Molecular Life Sciences. 2013, doi:10.1007/s00018-012-1002-9
• with Igor Chizhov, Björn Zorn, Wolfgang Gärtner: Kinetic and Thermodynamic Analysis of the Light-induced Processes in Plant and Cyanobacterial Phytochromes. In: Biophysical Journal. 2013, doi:10.1016/j.bpj.2013.09.033
• with Matthias Preller: Myosin structure, allostery, and mechano-chemistry. In: Structure. 2013, doi:10.1016/j.str.2013.09.015
• with M. B. Radke, M. H. Taft, D. Hilfiker-Kleiner, M. Preller und anderen: Small molecule-mediated Refolding and Activation of Myosin Motor Function. In: eLife. 2014, doi:10.7554/eLife.01603.
• with Stefan Münich, Manuel H. Taft: Crystal Structure of Human Myosin 1c – The Motor in GLUT4 Exocytosis: Implications for Ca2+-Regulation and 14-3-3 binding in J Mol Biol. 2014, doi:10.1016/j.jmb.2014.03.004
• with Hemma Brandstaetter, Folma Buss und anderen: Loss of functional MYO1C/myosin 1c, a motor protein involved in lipid raft trafficking, disrupts autophagosome-lysosome fusion. In: Autophagy. 2014, doi:10.4161/15548627.2014.984272
• with Curth Reubold und anderen: Crystal structure of the dynamin tetramer. In: Nature. Band 525, 2015, S. 404–408, doi:10.1038/nature14880
• with Julian von der Ecken, Sarah M. Heissler, Salma Pathan-Chhatbar, Stefan Raunser: Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution. In: Nature. Band 534, 2016, S. 724–728, doi:10.1038/nature18295
• with Krishna Chinthalapudi, Sarah M. Heissler, Matthias Preller, James R. Sellers: Mechanistic Insights into the Active Site and Allosteric Communication Pathways in Human Nonmuscle Myosin-2C. In: eLife. Band 6, 2017, doi:10.7554/eLife.32742
• with A. Meents und anderen: Pink-beam serial crystallography. In: Nature Communications. Band 8, 2017, doi:10.1038/s41467-017-01417-3
• with Rasmus D. Wollenberg, Manuel H. Taft und anderen: Phenamacril is a reversible and noncompetitive inhibitor of Fusarium class I myosin. In: Journal of Biological Chemistry. Band 294, 2019, S. 1328–1337, [1]
• with Johannes N. Greve, Frederic V. Schäbe, Thomas Pokrant, Jan Faix und anderen: Frameshift mutation S368fs in the gene encoding cytoskeletal β-actin leads to ACTB-associated syndromic thrombocytopenia by impairing actin dynamics. In: European Journal of Cell Biology. 2022, doi:10.1016/j.ejcb.2022.151216

Weblinks

• Dietmar Manstein at the Hannover Medical School.
• Publications by and about Dietmar J. Manstein on the document server Researchgate.
• Publications by Dietmar J. Manstein at Google Scholar
• Literature by Dietmar J. Manstein in Pubmed